Editor comment

Over the past 40 years, very little progress has been made worldwide in the outcome of treatment for oral cancer.
Despite advances in technology and implementation of multidisciplinary treatment programmes, only modest improvements in survival have been reported and these are attributed mainly to diagnosis at an early stage rather than to therapeutic interventions.
The molecular profiles for oral cancer have drawn much scientific interests during recent years.
For colleagues not working within the field of molecular biology, the literature may difficult to comprehend.  This review article may assist to increase the understanding of disease mechanisms and biomarkers of oral squamous carcinoma.

---

 

Curr Opin Oncol 18:228–233.2006

Disease mechanism and biomarkers of oral squamous cell carcinoma

Brigitta M.N. Brinkman (a) and David T.W. Wonga (b)
a) School of Dentistry, Dental Research Institute, University of California Los Angeles, Los Angeles, California, USA
b) Division of Head and Neck Surgery/Otolaryngology, David Geffen School of Medicine, Henry Samueli School of Engineering and Applied Sciences, Jonnson Comprehensive Cancer Center, University of California Los Angeles, Los Angeles, California, USA.

Abstract (Link to Pub Med Abstract)

PURPOSE OF REVIEW: This review focuses on oral cancer disease mechanisms and discusses ongoing research to identify molecular signatures or biomarkers for oral cancer. Other areas covered include the analysis, validation, and predictive value of these markers. 
RECENT FINDINGS: During the past years, progress has been made in the oral cancer genetic markers field, which includes alterations of the p53 tumor suppressor protein, the inactivation of cyclin dependant kinase inhibitors (e.g. p16) and the overexpression of the epidermal growth factor receptor. Many of these markers are thought to have potential clinical interest, yet few of them are being used in a clinical setting for oral cancer management. The particular modifications that characterize each step of oral cancer progression can now be profiled by several high throughput discovery techniques. Genomic and proteomic studies of oral cancer tissues, plasma, and saliva of oral cancer patients, have allowed the identification of several promising cancer signatures.
SUMMARY: Important progress has been made in the molecular understanding of oral cancer and its application for diagnosis, prognosis and treatment. The increased efforts in translational research will result in earlier diagnosis of oral cancer, better knowledge of prognostic factors, and the development of targeted treatment regimens based on patients' clinical and biological characteristics at presentation.